She is known for her role as Rosie Rivera on Telemundo's Netflix series Mariposa de Barrio and for her rising social media presence through her TikTok account.

Ana Wolfermann graduated from Coral Gables Senior High School in Miami, Florida in 2019 with a Bilingual International Baccalaureate Diploma.

In 2016, Wolfermann portrayed Sara Aguilar in television series Eva La Trailera where she shared scenes with Edith Gonzales and Javier Díaz Dueñas.

In a Telemundo live digital interview in 2018, Wolfermann explained that the role of Rosie Rivera allowed her to truly develop her talent at 15 years old, as she was challenged with interpreting scenes of complex psychological trauma, rebellion, fights, sexual abuse, and drug and alcohol consumption.

On her social media she shares her college lifestyle videos, her personal goals, advice to young girls, and her fashion interests, while focusing on promoting positivity, creativity and love.