If the Onemen Bay is considered part of the river, it also receives the Velikaya from the south and the Kanchalan from the north.

The country through which it passes is thinly populated, and is dominated by tundra, with a rich variety of plant life.

George Kennan, an American working on the Western Union Telegraph Expedition in the late 1860s, found that dog sled travel on the lower Anadyr was limited by lack of firewood.

Every year, on the last Sunday in April, there is an ice fishing competition in the frozen estuarine waters of the Anadyr's mouth.

The area is a summering place for a number of migratory birds including brent geese, Eurasian wigeons, and the pintails of California.