Anandham is a family drama with elements of business rivalry, romance, murders, and other intrigues typical of Tamil soaps interwoven into it.

The patriarch of the family – Radhakrishnan or RK – is an eminent industrialist whose blissful existence is threatened by a series of events involving his four children.

Shanthi, a widow with a child and married to RK's second son, Karthik, is the quintessential do-gooder in the serial but much of her early days were consumed by her struggle for acceptance within the family.

Subsequently, he reconciled with Shanthi and later accepted the remarriage of Madhan, who worked up the courage to dissolve his enforced marriage to Abhirami and return to his first love, Rohini.

In the latest phase of the serial, which has since been extended beyond its originally scheduled end date, the focus is again on the gathering storm in the lives of the RK family.

Madhan cannot come to terms with the fact that his wife Rohini chose to pursue her ambition of becoming a bank manager and accepting a transfer to Tirupathi while his mother was lying comatose.

Durai is a conscientious police officer whose blind devotion to duty cost him the affections of his girlfriend Priya, who was subsequently adopted by the RK household, allowing for the seamless switch from the main story to the sub-plot.