[2][3] The adaptation was created by Phil Baker and Drew Vaupen, two of the creators of the original Good Luck Charlie, because they believed the series would be a great appeal to everyone in Indian households, not just children and teens.

[4] In each episode, Dolly Singh, the older sister, creates a video diary with advice for Nikki on navigating their family and life as a teenager.

The series revolves around a Punjabi family in Delhi called Singh who are adjusting to the birth of their fourth child Nikita, nicknamed Nikki.

When parents Himani and Avatar Singh return to work, they ask their three older children Dolly, Rohan and Sunny to help raise their youngest sister.

The events in each episode become material for a video diary series that Dolly creates, which she hopes will one day provide useful advice for Nikki.

Sunny frequently challenges the nosy neighbour Roli Aunty, while Rohan and his best friend Popi work on their band and try to impress girls.

As the season's end, Avatar mistakenly frees an exotic termite that destroys the family home, forcing the Singhs to move.

The series ends with Rohan operating a food truck in partnership with Avatar, Dolly moving to Mumbai for studies, Bobby becoming the next chhota shaitan (devil child), Nikki finally accepting Bobby and Kritika as her siblings and Himani delivering her last and sixth child in addition to her work as host at her news company.

Rohan delivers food for Kukkad Nukkad (a chicken restaurant) and falls for a customer, Richa, who he obsesses over, causing friction with Popi.

When Nikki develops a habit of pushing buttons, Sunny blames her for leaving the garage door open and the theft of his bicycle – which he sold to his friend Shibu.

Dolly, Himani and Nikki take a trip to Mumbai to visit their rich great-aunt, but are mistaken for dance duo the Singh Sisters and taken to the Hotel Raj Mahal.

The third season of Best of Luck Nikki started airing on Disney Channel India on 7 July 2013 with the episode "Make Room for Baby".

A first look at Best of Luck Nikki season four was revealed in the Goldie Ahuja Matric Pass crossover episode "Happy Father's Day!"