[6] Since her debut single in 2016,[7] Birla has reached more than 350 million combined streams[8] and collaborated with artists including Sean Kingston, Afrojack, and Mood Melodies.

[13] In 2020, she launched the Ananya Birla Foundation to support mental health, equality, education, financial inclusion, climate change and humanitarian relief efforts.

[19] In March 2024, Ananya Birla's microfinance company Svatantra entered into a definitive agreement for an investment of ₹1,930 crore with private equity investors Advent International and Multiples.

[24] A remix by Dutch DJ Afrojack of "Livin’ the Life" makes Birla the first Indian artist to get a worldwide release through PM:AM Recordings and hit over 14 million views on YouTube as of June 2017.

She released her next single "Meant to be" in July 2017 which was subsequently certified Platinum as per the Indian Music Industry (IMI) recognised criteria for certifications.

[34] Later that year, she released “Let There Be Love”[13] and “Everybody's Lost”[35] becoming the first Indian artist to be featured on an American national top 40 pop radio show, Sirius XM Hits.

[36] In 2022, Birla made her acting debut after being featured in the song "Inaam" from Rudra: The Edge of Darkness, a streaming television series.

[37] She made her full-fledged acting debut in 2023, with a spy thriller titled Shlok: The Desi Sherloc, directed by Kunal Kohli.

[40] In 2020, in response to the COVID-19 pandemic, Mpower tied up with the Government of Maharashtra and Brihanmumbai Municipal Corporation (BMC) to launch a 24x7 free helpline.

[8] In July 2024, Ananya Birla collaborated with the Institute of Human Behaviour and Allied Sciences (IHBAS) to enhance mental health and career support for students in Delhi.

This initiative trained psychologists in therapeutic techniques, including art-based therapy, enabling children to express themselves through creative outlets.

The program aimed to reach over 30,000 students by March 2025[45] In April 2025, the Ananya Birla Foundation organized the 'Mpowering Minds Summit 2025' to drive urgent reforms in youth mental health.