A co-founder of the New Democracy party, he was a long-standing member of the Hellenic Parliament, governor of Samos and Lesbos prefectures, and held various posts as deputy minister in the first Karamanlis government (2004–07).
"[7] When in his last parliamentary term (2012–14), Nerantzis was elected president of the parliament's Special Permanent Committee on Institutions and Transparency, he was involved in several controversies.
After he had been criticized for procedural irregularities in late 2013,[8] in early 2014 he was accused by the opposition for withholding the "Nikoloudis Report" from the parliament.
The report named after Cassation Court investigator Panagiotis Nikoloudis listed 413 persons indicted for tax evasion and money laundering, including a number of local and regional government officials.
[10] In a parliamentary debate in September 2014, Nerantzis railed against the adoption of an anti-discrimination bill aimed at protective rights for same-sex couples.