[8] Klyosov immigrated to the US in 1989[9] after Mikhail Gorbachev came to power,[3] and from 1990 to 1998 he was a visiting professor of biochemistry at the Center for Biochemical and Biophysical Sciences at Harvard Medical School.
[10][11] From 1996 to 2006 Klyosov worked at a subsidiary of Kadant, where he applied enzymology to processing of waste products from the paper-making industry, and following advice from a friend in the plastics industry, helped create a business that used cellulose granules as filler material for plastic composite products.
[2] Pro-Pharmaceuticals named a new CEO in March 2011,[14] and gave Klyosov a one-year contract to continue as CSO the same month.
[4] From 2008[17] Klyosov is also known as the author of what he calls "DNA genealogy", aimed to synthesize biology, anthropology, archaeology and linguistics and to implement methods of chemical kinetics in genetics.
[18][20] A 2015 open letter from scientists in various fields said that his writing could fuel hatred “attracting readers whose nationalist and political ambitions are not satisfied with the world’s scientific body of knowledge.” Klyosov responded saying that they were members of a "fifth column".
[22][23][24] Klyosov is the founder and president of the Academy of DNA Genealogy[18] and self-publishes its proceedings via Lulu.