And Then Nothing Turned Itself Inside-Out is the ninth studio album by American indie rock band Yo La Tengo, released on February 22, 2000, by Matador Records.

And Then Nothing Turned Itself Inside-Out was recorded at Alex the Great in Nashville, Tennessee, and mixed at the Big House in Manhattan, New York City.

[2] And Then Nothing Turned Itself Inside-Out marks a creative shift in Yo La Tengo's songwriting with a greatly slower approach.

The album also features an array of backing instruments such as vibraphone and drum machines, which all lend an expansion of musical textures and differentiation of timbre.

However, their noise rock influence is also most present in songs like "Saturday", "Cherry Chapstick", "Tired Hippo", and the 17-minute epic "Night Falls on Hoboken".

AllMusic reviewer Heather Phares felt that the album "isn't as immediate as some of the group's earlier work, but it's just as enduring, proving that Yo La Tengo is the perfect band to grow old with".