Real-life husband and wife Stephen Root and Romy Rosemont guest starred as a married couple behind the time loop, one an electrical engineer and the latter a professor of theoretical physics.
Peter Bishop (Joshua Jackson), who has only recently appeared unexpectedly in an alternate timeline (not Walternate's), is still being held by Fringe division, whose members have yet to come to fully trust him.
Walter Bishop (John Noble) still disbelieves that Peter is his son, but, under orders from Broyles (Lance Reddick), studies him as a test subject.
Inside, he finds that Raymond, a skilled electrical engineer, used Kate's research to construct a giant machine in the basement of their house that creates a temporary time bubble.
Raymond has used the machine to revert their home to the state four years prior, before Kate fully suffered from rapid deterioration of Alzheimer's, and has been convincing her younger version to complete her research to allow him to stabilize the time bubble permanently.
As Peter discusses this with the FBI, Kate reveals she has completed the proper equations, and Raymond asks her to write them out in a notebook so that he can recreate the time bubble machine in a remote location.
The Fringe division and the FBI remove the time bubble equipment from the house; Raymond, having kept Kate's notebook, discovers that she had blacked out all the equations, leaving a final message to him to keep on living his life and giving her his love.
The episode was co-written by executive story editors Glen Whitman and Robert Chiappetta, while former Fringe producer, Brad Anderson, directed.
[2] This episode guest stars real-life husband and wife Stephen Root and Romy Rosemont portraying the roles of Raymond and Kate Green, and is the first time they have played alongside each other in a creative work.
"[4] Writing for Entertainment Weekly, Jeff Jensen believed the episode was "high grade Fringe, in my opinion, heartfelt and heady, a fraternal twin to the season 2 classic 'White Tulip.
'"[5] Jensen in particular highlighted the scene involving Peter's time-jumps while the Fringe team is investigating train tracks, comparing it to the experiences of main character Billy Pilgrim in the novel Slaughterhouse Five.
[2][5][8] Jeff Jensen of Entertainment Weekly named "And Those We've Left Behind" the tenth best episode of the series, calling it "an episode worthy of one of Fringe's key inspirations, The Twilight Zone, with exceptional guest players taking center stage in a clever, wise, emotionally rich story in which an electrical engineer fought an unwinnable battle to gain more time with his beloved, Alzheimer's-affected genius wife via time travel tech.