[2] The park is between the cities of Lower Lake and Clearlake on State Route 53, north of Calistoga in the wine country.

Aquatic and terrestrial wildlife include: large mouth bass, bluegill, catfish, crappie, the north-western pond turtle, bats, gray fox, frogs, garter snakes, mink, muskrats, opossums, raccoon, river otter, skunks, and toads.

[6] The Southeastern Pomo Native Americans, one of the largest groups of indigenous peoples of the Americas in pre-Columbian California, lived in the area of present-day Anderson Marsh State Historic Park, and their descendants continue to do so nearby.

[8] Scotsman John Still Anderson, with his wife and six children, bought the property from Grigsby in 1884, built what is now known as the Ranch House, and ran a dairy and raised beef cattle.

[5][8][9] The park offers bird watching, hiking, a bluegrass musical festival, and interpretive programs, including a historic ranch home.