The team was founded and owned by brothers Ike W. and John B. Duffey, founders of meat packing company Duffey's Incorporated, which had purchased the Hughes-Curry Packing Co. of Anderson in 1946, at which time the brothers founded the Anderson Packers.

John Duffey was president of the club, and its secretary-treasurer was Ike.

The Duffeys profitably sold their Anderson packing plant three years later, although they retained ownership of the team until its demise.

The team moved into the National Basketball Association for the 1949–50 season.

The franchise withdrew from the NBA on April 11, 1950, when the organization was absorbed by the league.