When Andersson's cabinet took office on 30 November 2021, it became the smallest Swedish government since 1979, relying on only 100 of 349 parliament members (28,65%).

On 14 September 2022, following the election in which her support coalition lost their parliamentary majority, Andersson announced that she would tender her resignation as Prime Minister on the following day.

[6] Since Andersson was elected by parliament with the promise of retaining the Social Democratic-Green coalition she had no choice but to resign only seven hours after being approved.

Member of Parliament Nina Lundström from the Liberals decided to rebel against her party and thus not vote 'no' but abstain instead to Andersson becoming prime minister saying that electing her is the only way to keep the Sweden Democrats from power.

A specific policy manifesto were presented when Andersson held her declaration of government (regeringsförklaring) 30 November 2021.