[5][6] He made his first team debut on 17 September 2015 in the UEFA Europa League against FC Groningen, where he provided an assist in a 3–0 victory for Marseille.

[8] On 16 May 2018, Zambo Anguissa played in the 2018 UEFA Europa League final, which Marseille lost against Atlético Madrid at the Parc Olympique Lyonnais in Lyon, France.

[13] On 31 August 2021, Zambo Anguissa signed a new three-year contract with the Championship club before heading out on loan to Napoli for the 2021–22 season.

[19] Zambo Anguissa made his international debut for the Cameroon national team in a friendly 1–0 win over Tunisia on 24 March 2017.

[26][27] At the end of the 2022 calendar year, Zambo Anguissa would be called up by new national team manager Rigobert Song to Cameroon's squad for the 2022 FIFA World Cup in Qatar.