Born in Maracaí[2] but raised in Pedrinhas Paulista, both in the São Paulo state,[3] André Anderson joined Santos FC's youth setup in 2009.
[8][9] He made his professional debut on 4 November, coming on as a second-half substitute for Antonio Palumbo in 1–0 away loss against Venezia.
[10] André Anderson scored his first professional goal on 18 January 2019, netting the equalizer in a 2–1 away defeat of Palermo.
[11] Back from loan in July 2019, he was included in Lazio's first team squad, and made his Serie A debut on 1 December, replacing Luis Alberto late into a 3–0 home win over Udinese.
On 11 April 2022, André Anderson joined São Paulo on loan until 30 June 2023, with an option to buy.