On July 22, 2014, the United States Senate unanimously confirmed Birotte to serve as a district judge in Los Angeles after being nominated by President Barack Obama.

[1] Four years later, he joined Quinn Emanuel Urquhart & Sullivan where he represented individuals charged with white collar crime.

[1][6] Birotte was appointed to the United States Attorney's office by President Barack Obama and confirmed by the Senate in February 2010.

[9][6] Birotte was the United States attorney investigating charges against former cyclist Lance Armstrong for defrauding of the government, drug trafficking, money laundering and conspiracy.

On February 5, 2013, Birotte stated that Armstrong's subsequent admission that he took drugs was no reason to reopen the original investigation.

[15] On July 16, 2014, Senate Majority Leader Harry Reid filed a motion to invoke cloture on Birotte nomination.