He is executive chairman of tobacco giant Philip Morris International (PMI), having previously been CEO.
On March 28, 2008, he was appointed to the role of Chief Operating Officer when PMI was established as a separate entity.
"[4] In December 2020, Philip Morris International announced that its chairman Louis Camilleri would be stepping down, to be replaced by Calantzopoulos.
Prior to this sale, the CEO of PMI sold 30,000 shares for $2.8 million, an average of $93.15 each on Feb 12, 2013.
[6] Calantzopoulos was on the SMPM AB International board of directors – a joint venture between Swedish Match and PMI before its dissolution.