[b] The character's return in 1993 saw him feud with John Black (Drake Hogestyn) for the affections of Stefano's adopted daughter Kristen Blake (Eileen Davidson).
With his cover blown, André's treachery continues and Stefano disowns him and the character seemingly commits suicide by unplugging his own life support in October 2007.
In January 2018, André is killed via blunt force trauma by an unknown person, which was later revealed to be Abigail Deveraux in self-defence.
André's other victims include Stefano's daughter Renée DuMonde, Nurse Kelly Harper (Robin Eisenman), Marlena's cousin Trista Evans (Barbara Crampton), and Letitia Bradford (Ruth Buzzi).
During his time posing as Tony, André also goes after Gwen Davies (Anne-Marie Martin), Police officer Joan Hopkins (Sheila deWindt), and Hope Williams (Kristian Alfonso) – all of whom managed to survive.
In November 1984, André hijacks a plane on its way to Haiti and it crashes on a deserted island killing Tony's mother Daphne (Madlyn Rhue).
In the meantime, "Tony" befriends Billie Reed (Lisa Rinna) and helps her regain control of her cosmetics company Countess Wilhelmina when he buys 49% of Titan Industries.
"Tony" and Kristen are about to marry again when John interrupts the ceremony claiming to have evidence linking Stefano to the murder of Billie's father Curtis (Nick Benedict).
Having learned of her husband's deception and attempts to get her pregnant by switching her birth control pills, Kristen leaves "Tony" for John.
"Tony" abandons his plans and eventually regains his eyesight but hides that fact hoping to catch Kristen and John in bed together.
However, "Tony" steals his blood pressure medication which leads to Father Francis suffering a heart attack that renders him comatose.
As "Tony" attends the wedding of his adopted brother Peter Blake (Jason Brooks) and Jennifer Horton (Melissa Reeves), he manipulates John into threatening to kill him in public.
"Tony" makes a shocking return from the dead in the summer of 2002 when he crashes John and Marlena's anniversary celebration, having survived getting shot and still suffering his blood disease—which turns out to be a lie that Stefano convinced him.
[10] "Tony" fakes his death again after a confrontation with John only to continue to wreak havoc from the beyond the grave as he causes an explosion that nearly kills some of the captives as they try to escape the island.
EJ foils their plans and kidnaps Stefano in exchange for "Tony" agreeing to end the feud between the Brady and DiMera families.
However, it isn't until "Tony" fakes his half sister Lexie (Renée Jones)'s death and tries to kill Bo and Hope when they rescue her that Stefano realizes he has created a monster.
During a scuffle, Bo forces André to reveal Tony's whereabouts and just before he falls of a roof and ends up in the hospital where he escapes having faked his injuries.
Shawn Brady saw a chance to end André's reign of terror by turning off his life support but couldn't bring himself to do it.
André buys up Aiden Jennings (Daniel Cosgrove)'s debt in order to keep him in line with Stefano's schemes.
André publicly announces himself at the wake of Will Horton (Guy Wilson) in October 2015 where his apology for his past misdeeds falls on deaf ears.
André orders Aiden to kill Hope Brady on their wedding night and collect the insurance money to repay his debt.
Sami escapes and empties all of Stefano's accounts, so André brainwashes Chad to seduce Belle and find out where the money is hidden.
André and Theo helped Abby delete the photo of Chad standing over Deimos’ dead body, wiping the knife clean.
On Abby's advice, André kissed Kate on New Year's Eve, but the festivities were interrupted by the arrival of Vivian Alamain and her long lost son with Stefano, Stefan.
It is later revealed that Abigail killed him partly in self-defence, but she later suffered from multiple-personality disorder and Dr Laura, one of her alters, had blocked it out of her memory for protection.
"I think they were looking to bring on a real villain, to not only create big conflict in Salem but to build up the dynasty," Penghlis said of the writers' decision to revive André instead of Tony (who historically is not a biological DiMera).
[15] André is back to watch over his father who has recently suffered a heart attack and he isn't happy with how Stefano has been treated lately.
[15] In 2020, Charlie Mason from Soaps She Knows placed Tony and André jointly at #28 on a list of the 35 most memorable characters from Days of Our Lives, commenting that "Thaao Penghlis’ lookalike connivers have to share an entry, if only because during any given era, we could never be sure which of them we were really watching.