He enjoyed the patronage of Cardinal Richelieu, a native of the same district with himself, through whose influence he was appointed historiographer and geographer to the king.
Several of his larger works were continued by his only son François Duchesne (1616–1693), who succeeded him in the office of historiographer to the king.
[1] The principal works of André Duchesne are Les Antiquités et recherches de la grandeur et majesté des rois de France (Paris, 1609), Les Antiquités et recherches des villes, châteaux, &c., de toute la France (Paris, 1609), Histoire d'Angleterre, d'Ecosse, et d'Irelande (Paris, 1614), Histoire des Papes jusqu'à Paul V (Paris, 1619), Histoire des rois, ducs, et comtes de Bourgogne (1619–1628, 2 vols.
Besides these Duchesne published a great number of genealogical histories of illustrious families, of which the best is that of the house of Montmorency.
André also published a translation of the Satires of Juvenal, and editions of the works of Alcuin, Abelard, Alain Chartier and Étienne Pasquier.