André Furtado de Mendonça led the forces of a company of 1,400 Portuguese and 3,000 lascarins against King Puviraja Pandaram as the second expedition in Mannar and gained victory, and continued his campaign to the heartland of the Jaffna kingdom.

Gradually, the incumbent king resisted Portuguese overlordship until he was ousted and hanged by Filipe de Oliveira in 1619.

[7]: 166 In 1598, he destroyed a fleet of Kunjali Marakkar naval captain of Zamorin of Calicut, and in 1600 Mendonça attacked and captured his fortress.

In April 1606, Portuguese forces under the captainship of André Furtado were besieged in Malacca by a Dutch fleet under the command of Cornelis Matelief de Jonge.

[12]: 187 [13] He died due to illness in April 1611 and buried at the church of Covenant of Grace (Portuguese: Convento da Graça) in Lisbon.