[2] As of November 2020, his estimated net worth is US$5.71 billion[3] As a philanthropist, he has been an advocate for sustainability and environmental protection,[4] serving as International Vice-president of the World Wide Fund for Nature (WWF) from 2007 to 2017.

[10] In 1996, he became a member of the board of Roche holding, the world's second-largest pharmaceutical company, established by his grandfather.

[12] An early investor in the Maryland-based start-up Inovalon, which manages and analyses healthcare data,[9] and is a non-executive director.

[14] Hoffmann is an environmentalist,[15] involved in a number of nonprofit organizations and initiatives related to sustainability and nature conservation.

[17] In 2016, he became president of Fondation Tour du Valat, a French research institute dedicated to Mediterranean wetland conservation.