In the 2007 Open Championship, Romero placed third, behind Sergio García and Pádraig Harrington, making ten birdies on the last day of play.

In July 2007, Romero broke into the top 100 of the Official World Golf Ranking for the first time and he reached a new best of 29th after his Players Championship of Europe win.

In March 2008, Romero won for the first time on the PGA Tour at the Zurich Classic of New Orleans, and moved to a career high of 21 in the rankings.

[4] In 2008 he overtook fellow Argentine Ángel Cabrera to become the highest ranked South American golfer for a short period until he was surpassed by Camilo Villegas of Colombia.

European Tour playoff record (0–1) *Note: The 2006 Torneo de Maestros was shortened to 54 holes due to weather.