[2] Santiago spent the 2013 season with Chattanooga, posting a 5-12 record and 4.97 ERA with 109 strikeouts in 134 innings of work across 30 games (25 starts).

[5] In 26 appearances split between the Double-A Tennessee Smokies and Triple-A Iowa Cubs, he registered a 4-5 record and 3.89 ERA with 55 strikeouts across 78+2⁄3 innings pitched.

In 22 appearances (8 starts) for the Miners, Santiago compiled a 2-6 record and 4.50 ERA with 55 strikeouts and 6 saves over 60 innings of work.

Santiago spent the 2018 season with Mississippi and Gwinnett, posting an aggregate 6-6 record and 4.61 ERA with 78 strikeouts in 105+1⁄3 innings pitched across 26 games (15 starts).

[10] Santiago played in 2 Pan American Games (2011 México and 2015 Toronto), a World Cup (2011 Panama), 5 Caribbean Series for Puerto Rico (2013, 2015, 2016, 2017, 2018), Premier12 (2015 Japan, Taiwan, Taipei).

Santiago later pitch 6+2⁄3 of work against Chinese Taipei, striking 5 batters to help Puerto Rico advance to the quarterfinals.