He played college football at Florida State and was selected in the third round of the 2008 NFL draft by the Detroit Lions.

Serving as a back-up to Brodrick Bunkley, he finished the year with six tackles, including one for loss, and two pass breakups.

As a junior, Fluellen faced the task of replacing Bunkley at the nose guard position, named one of the “ten toughest vacancies” in college football.

[3] Bunkley's original successor, junior college transfer Paul Griffin, tore the anterior cruciate ligament in his left knee in the first quarter against Troy, the second game of the season.

[5] He was named to several preseason All-American and All-Atlantic Coast Conference teams, but managed to start only five games, missing three entire contests due to a left elbow hyperextension.

He ended the season with 21 tackles (10 solos), including two sacks, one pressure and a pair of pass deflections.

[7] In four years with the Lions, Fluellen played 51 games, recording 48 tackles and 2.5 sacks, starting five times.

He played two games with the Dolphins,[8] who released Fluellen on October 2, 2012 upon McDaniel's return to the active roster.

[17] On October 7, 2015, Andre Fluellen was signed by the Detroit Lions after Tyrunn Walker was placed on injured reserve.