Rwisereka was born on 31 December 1949 in Rusenge, Nyaruguru, Southern Province, Rwanda.
In the early 1960s he went into political exile in the Democratic Republic of Congo, where he was a senior member of the Rwandan Patriotic Front during its struggle to liberate Rwanda.
[1] Rwisereka was also principal of Form Four program educational secondary school in RDC called Institut Mapambazuko de Kiliba from 1975-77, married for short-time to the niece of the Legal Representative of the Pentecostal Churches Association in Zaïre.
Vice-President of the Democratic Green Party of Rwanda Andre Rwisereka was found murdered and partially beheaded near a wetland in Butare on 14 July 2010.
The party chairman (president) Frank Habineza was among opposition leaders who called for an independent international investigation into the murder, which may have had a political motivation.