Wetzel started his coaching career in 1997 when he joined ADO Den Haag as assistant manager.

His first managerial role came in 2004 when he took over the reins at Willem II Tilburg after being assistant there for two years.

He returned to management in 2005 with Belgian Second Division club KV Mechelen.

In April 2009 he was moved into a technical directorship position, with Raymond Atteveld replacing him, only to be dismissed altogether later in December.

On 9 December 2010, United Arab Emirates side Al-Jazira Club appointed him as a technical director.