He made his debut for the club in 2012 before enjoying loan spells with Derby County, West Bromwich Albion, Norwich City, and Red Bull Salzburg.

Wisdom has also played for and captained the England youth teams at various levels, and was part of the squad which won the UEFA European Under-17 Championship in 2010.

[10] The appointment of Brendan Rodgers in June 2012 would be Wisdom's fourth manager during his time at Anfield and would present him with a fresh opportunity to stake a claim in the first team.

[11] In September, Wisdom would travel with several other Liverpool youngsters to Switzerland for their UEFA Europa League group tie versus Young Boys.

[19] An ever-present in the team, he left the club in May 2014 after playing at Wembley against QPR in the Championship play-off final, which Derby lost by the only goal of the game.

[22] Having signed a new four-year contract with Liverpool ahead of the 2015–16 season on 26 May 2015,[23] Wisdom joined Premier League newcomers Norwich City on a season-long loan on 29 July 2015.

[29][30] After his release by Derby County, Wisdom trialled with Portsmouth, Birmingham City, Sheffield United and Polish club Warta Poznań.

[35] He made a total of 12 appearances for the club, the last of those coming on 10 November 2024, in the 2024 FAI Cup final, which his side lost 2–0 to Drogheda United at the Aviva Stadium.

[40][41][42] England defeated France 2–1 in the semi-final with both goals coming from Ipswich Town striker Connor Wickham as they booked their place in the final for the second time in four years.

[43] Wisdom started the final versus Spain and equalised for England on the half-an-hour mark with a header from a corner after initially going a goal down.

[49] Wisdom was appointed as captain of the England U21 side in 2013, however in his first game in the role, a qualifier against Finland, he was sent off the pitch with a straight red card after kicking an opponent intentionally.