On 20 May 2011, he won his first regional championship—the vacant WBC Silver International super-middleweight title—via unanimous decision over Ruben Eduardo Acosta.
In his following fight, on 11 November 2011, Di Luisa suffered his first professional loss when he was stopped in the twelfth and final round by Mouhamed Ali Ndiaye.
His next attempt, almost exactly a year later on 23 November 2012, was also unsuccessful: this time he lost via corner retirement to Christopher Rebrasse.
On 20 December 2014, the third attempt would be the charm for Di Luisa, as he stopped Roberto Cocco in eleven rounds to win the vacant European Union super-middleweight title.
Having vacated the title, Di Luisa next fought former super-middleweight world champion Lucian Bute on 15 August 2015, but was stopped in four rounds.