He raced with WithU Yamaha RNF MotoGP Team for the 2022 season but announced his intended-retirement after the Misano round in September.

[1] Dovizioso was the 2004 125cc World Champion, but is best known for his time with the Ducati Team in the MotoGP class, finishing championship runner-up to Marc Márquez for three consecutive seasons in 2017, 2018 and 2019.

He made his debut in MotoGP in 2008 and immediately finished 5th in the standings as the top satellite rider earning a move to the Factory Honda team in 2009.

In his three seasons with Repsol Honda, he scored 15 podiums, including a maiden MotoGP win at Donington Park, and had a highest championship position of 3rd in 2011.

A documentary film about Mancini's career, released in 2016 by director Jeffrey Zani, tells the story of that racing season.

[10] On his premier class debut, Dovizioso achieved a highly credible fourth place, at the season opener in Qatar, passing Valentino Rossi on the final lap.

For the 2009 season, Dovizioso became an official Repsol Honda rider replacing Nicky Hayden and partnering Spain's Dani Pedrosa.

[11] In July 2009, Dovizioso won his first race in MotoGP at the British Grand Prix in wet conditions at Donington Park.

Dovizioso had a strong start to his second season with the Repsol Honda team, picking up a podium in the season-opening race in Qatar.

Despite this, Dovizioso consistently collected points finishes and claimed his first pole position in MotoGP at the Japanese Grand Prix at Twin Ring Motegi.

Dovizioso remained with Repsol Honda for a third consecutive season in 2011, riding in a three-bike team alongside Casey Stoner and Dani Pedrosa.

He took fourth place in Portugal, with a late-race pass on Valentino Rossi, before Le Mans saw Dovizioso's best performance of the season to that point.

[19] Dovizioso had a difficult season on an under-performing Ducati Desmosedici, with a best place of fourth in wet conditions at the French Grand Prix.

Dovizioso remained at Ducati for a third successive season, where he was joined by fellow Italian rider, Andrea Iannone, who moved from Pramac Racing.

In the inaugural Austrian Grand Prix, where Ducati were favourites to win, he finished 2nd to his teammate Iannone, which left disappointed.

He was taken out again in Argentina, this time by Aleix Espargaro, before finishing 6th, 5th, and 4th in Austin, Jerez and Le Mans, however Ducati was pretty far behind the winner in those races.

He again took back-to-back wins in Austria and Great Britain, retaking the lead as Marquez retired due to blown engine.

At the San Marino grand prix, he finished third and a 7th position at Aragon saw him lose the title lead to Marc Marquez once again.

Dovizioso won at Qatar for the second year in a row and in Austria with a final corner overtake on Marc Márquez.

[22][23] He suffered a large accident at the British Grand Prix, where he was unable to avoid the low-siding Fabio Quartararo in front of him, running over the French rider's bike, sending Dovizioso airborne and falling head-first to the ground heavily.

By the end of 2020, with no other immediate prospects, Dovizioso elected to take a sabbatical year in 2021 with his sights set on returning to racing for 2022.

[29][30] Ultimately, the 2022 seat went to Spanish rider Maverick Viñales, who started with Aprilia early in September 2021,[31] closing the door for Dovizioso with the Noale manufacturer.

Dovisioso returned to the rebranded WithU Yamaha RNF MotoGP satellite team, partnering with Darryn Binder.

He was officially appointed by Yamaha as a substitute test rider, replacing Cal Crutchlow who was absent due to injury.

Dovizioso's reappearance at Yamaha comes after he spent time testing their YZR-M1 in the second half of last season, replacing the injured Cal Crutchlow.

[37] He raced as a substitute driver for Pietro Fittipaldi, who was briefly loaned to Team Rosberg from WRT as Jamie Green was absent due to appendicitis recovery.