He grew up in his native town, receiving musical and general education from his elder brother Matteo, a priest, public tutor and organist.
The protection of the nobleman Jseppo Morosini enabled him to study with eminent musicians: Gioacchino Cocchi, Padre Paolucci, Giuseppe Saratelli, Domenico Gallo, Ferdinando Bertoni and (the best-known of them) Baldassare Galuppi.
[4] At the end of 1771, Luchesi traveled to Bonn on a three-year contract, invited by the Prince Elector Archbishop of Cologne Maximilian Friedrich von Königsegg-Rothenfels, who wished to raise the quality level of his court orchestra.
[3] When the court organist Christian Gottlob Neefe temporarily replaced the Kapellmeister as conductor and teacher during his 1783-84 absence, Luchesi assigned the organ service to the very young Beethoven.
There is also no evidence of Luchesi's having taught other young Bonn musicians who went on to international renown: Antonin Reicha, Bernhard and Andreas Romberg, and Ferdinand Ries.