[2] He was the son of a court painter, Franz Hubert Müller [de] who, in 1817, became Director of the Grand Ducal gallery in Darmstadt.
The following year, to improve his oil painting techniques, he transferred to the Kunstakademie Düsseldorf, under the direction of Friedrich Wilhelm von Schadow.
Most of the work was done under his direction, but his personal contribution consisted of four panels near the transept, depicting the life of Saint Apollinaris.
In 1855, he was appointed a Professor at the Kunstakademie, succeeding Karl Josef Ignatz Mosler [de], who had retired.
Nevertheless, he became involved in restorative work; notably on an Assumption by Rubens, at the request of Adolf I, Prince of Schaumburg-Lippe.