Andrei Prepeliță was born on 8 December 1985 in Slatina and started playing organized football under the guidance of his father, Constantin at CSȘ Slobozia.

[1][2] He completed his junior years at Argeș Pitești, being brought there by Viorel Moiceanu, making his debut for the first team when coach Ion Moldovan sent him on the field on 7 May 2003 in a Liga I match which ended with a 1–0 loss against Gloria Bistrița.

[1][2] After playing 112 Liga I matches in which he scored 11 goals, Prepeliță was transferred by Argeș together with teammate Ciprian Tănasă to Universitatea Craiova for 1.5 million €.

[10][11][12][13][14] On 1 July 2015, he signed a two-year contract with Ludogorets Razgrad in Bulgaria, where he played alongside fellow Romanians Cosmin Moți and Claudiu Keșerü, winning the Bulgarian league title.

[1][29][30] Andrei Prepeliță played 14 games for Romania, making his debut under coach Victor Pițurcă, when he came as a substitute and replaced Ovidiu Hoban in the 84th minute of a Euro 2016 qualification match which ended with a 1–0 away victory against Greece.