Andrew Best Semple (3 May 1912 in Glasgow – 15 November 2013 in Northamptonshire) was a Scottish doctor who specialised in public health.

During the Second World War he served in the Royal Naval Reserve, electing for active service in the Second Submarine Flotilla, where he gained the rank of surgeon commander.

While in this role, he noticed that submariners struggled to adjust their eyesight while moving between brightly lit interiors to the dark observation tower.

He was particularly interested in tackling the problems of undiagnosed tuberculosis and poor housing in the city.

He was a member of the Royal College of Physicians and worked closely with the World Health Organization.