[3] As Arion Press’s designer, master printer, and editor, Hoyem used techniques of printing from metal type going back to Gutenberg and revived the turn of the century tradition of the livre d’artiste, matching literature with original work by major contemporary artists, including William Kentridge (The Lulu Plays), Jasper Johns (Poetry of Wallace Stevens), John Baldessari (Tristram Shandy), Kiki Smith (Poetry of Emily Dickinson), Richard Diebenkorn (Poetry of W. B. Yeats), Wayne Thiebaud (Invisible Cities, The Physiology of Taste), Alex Katz (Poetry of Bill Berkson), Martin Puryear (Cane), R. B. Kitaj (The Wasteland, Kaddish, Exit Ghost), Robert Motherwell (Ulysses), and Jim Dine (The Apocalypse, Biotherm, Case Study of the Wolf-Man, Temple of Flora).
Hoyem has published such contemporary writers as Seamus Heaney (Squarings, Stone from Delphi), Robert Alter (Genesis, translation), Tom Stoppard (Arcadia), Lawrence Ferlinghetti (A Coney Island of the Mind), David Mamet (American Buffalo), and scholars Helen Vendler (editions of Wallace Stevens, Allen Ginsberg, Shakespeare’s sonnets, and Melville), Arthur Danto (Henry James, Wittgenstein’s On Certainty), and Richard Wollheim (Freud), as well as classics by Cervantes (Don Quixote), Emily Dickinson, Jane Austen (Sense and Sensibility), T. S. Eliot, Dickens (A Christmas Carol), Flaubert (Bouvard and Pecuchet), Benjamin Franklin (Autobiography), Herman Melville (Moby-Dick, poetry), Pushkin (Eugene Onegin), Walt Whitman (Leaves of Grass), Sappho, Wallace Stevens, Hart Crane (The Bridge), Laurence Sterne, Shakespeare, and others.
From 1974 to 2018, he published 113 limited-edition books under the Arion Press imprint, including such monumental undertakings as Melville's Moby-Dick, Joyce's Ulysses, and a folio Bible.
The scholar James D. Hart, writing in Fine Printing: The San Francisco Tradition,[6] characterized Hoyem's books "as marked by an unusual inventiveness", praising the handset folio edition of Moby-Dick as a "majestic volume", among Arion's "virtuoso performances".
The Christian Science Monitor reported that "From melting the lead, to proofreading, to physically lifting 40-pound frames of type, the consensus of Andrew Hoyem, as publisher of the Arion Press, and his small crew of eight craftspeople, is that a hand-wrought Bible is intrinsically valuable”.
"[13] In 2000 Hoyem's operation was threatened by eviction, requiring the logistical challenge and expense of moving over 140 tons of equipment and metal type to a suitable new facility.
In response, Hoyem founded the nonprofit Grabhorn Institute to preserve and continue the operation of one of the last integrated facilities for typefounding, letterpress printing, and bookbinding.
As executive director of the Grabhorn Institute, he took on the role of educator, presenting an apprenticeship program, college courses, and a series of gallery exhibitions and lectures.