He was previously the political editor of The Daily Monitor, a Ugandan newspaper, and was the presenter of Andrew Mwenda Live on KFM Radio in Kampala, Uganda's capital city.

In 2013, he cofounded a social enterprise, Tugende, with Michael Wilkerson and Matt Brown, a company dedicated to helping young people own assets from which they derive their livelihoods.

Tugende has since been one of the fastest growing companies and now boasts of over 25,000 customers who are owners of such assets and another 30,000 who are in the process of securing ownership through micro finance loans.

(https://www.huffingtonpost.co.uk/richard-dowden/reconciliation-for-kagame_b_943271.html) In 2005, he was among sixteen senior journalists invited by the British government to discuss with Prime Minister Tony Blair the forthcoming report of the Commission for Africa.

An admirer of Socrates, Karl Popper, and Frederick Von Hayek, he is an activist, a journalist, a columnist, a part-time poet, a businessman, and a social entrepreneur.

[2][4] Mwenda is a recognised African voice in the global debate on the failures of foreign aid to Africa and the need for investment and trade as drivers of growth.

[1] Mwenda worked as a political editor of the Daily Monitor and general manager of its affiliate on FM radio, KFM, before establishing The Independent in 2007.

During his radio programme, the journalist accused the Ugandan government of "incompetence" and said they had put Garang on "a junk helicopter at night, in poor weather over an insecure area".

He has written widely on the effects of aid on the development process in Africa and been published in such prestigious newspapers as the International Herald Tribune and Der Spiegel and done radio and television documentaries for the BBC on this subject.

On social media, he declared that the cause of the UNPDRF was "battle Museveni's corrupt dictatorship, Besigye's radical extremism and Bobi Wine's empty-headed demagoguery.