Andrew Mwesigwa (born 24 April 1984) is a Ugandan former international footballer who played as a defender.

Mwesigwa began his career in 2002 with Ugandan side Villa SC, before moving to Icelandic club ÍBV in 2006.

[2] In February 2013, Mwesigwa extended his contract with Ordabasy,[3] after winning the Kazakhstan Super Cup with them in 2012.

[7] Later on in 2015, Mwesigwa played for Yenicami Ağdelen in the KTFF Süper Lig,[8] before leaving in January 2016.

[9] After leaving Yenicami Ağdelen, Mwesigwa went on trial with V.League 1 side Hà Nội,[10] which in 2016 was moved to Ho Chi Minh City and renamed Sài Gòn F.C.