[2] A Republican, Ferguson was nominated by U.S. president Joe Biden in July 2023 to serve as a member of the Federal Trade Commission.

[6] Ferguson's nomination was reported favorably by the United States Senate Committee on Commerce, Science, and Transportation on October 18, 2023, by voice vote.

[12][13] In October 2024, Ferguson argued in a partial dissent from a disqualification motion that the removal protections provided to the commission's administrative law judges are unconstitutional.

[14][15] In January 2025, Ferguson was chosen by Donald Trump to chair the FTC, replacing Lina Khan, officially taking up the position following the President's inauguration.

[1] He has stated intentions to ease his predecessor's scrutiny of business mergers and acquisitions, while continuing critical oversight of big tech platforms.