Andrew Rainsford Wetmore (August 16, 1820 – March 7, 1892) was a New Brunswick politician, jurist, and a member of a prominent United Empire Loyalist family.
His opposition to Canadian confederation dissolved when he didn't get the appointment he expected as Attorney-General in the Anti-Confederate Party's government.
Wetmore was able to assume the leadership of the remaining Confederation Party forces in the legislature becoming Premier in 1867.
Wetmore's government helped finance extensions to rail lines in the province.
His government also incorporated the College of Saint Joseph and granted full property rights to all married women living apart from, or deserted by, their husbands.