Wilkinson served as Minister of Justice and Attorney General from June 12, 2017, until an NDP minority government was sworn in the following month.

[11] On February 17, 2022, he resigned from the Legislative Assembly of British Columbia to allow for newly-elected BC Liberal leader Kevin Falcon to run in a by-election.

Three years into medical school, he was awarded a Rhodes Scholarship to study at the University of Oxford where he obtained his first law degree.

[14] After medical school, Wilkinson worked for a few years as a doctor in Campbell River, Lillooet and Dease Lake before making the switch to law.

[15] In 2006, after leaving his post as a deputy minister in Gordon Campbell's BC Liberal government, Wilkinson joined the Vancouver office of McCarthy Tétrault, a major national law firm, where he practised as a litigator.

In 2006, he returned to the private sector by becoming a partner in the Litigation Group of McCarthy Tétrault[17] He remained active in Liberal politics in the intervening years, having served as riding president of Federal MP Joyce Murray and briefly as BC campaign co-chair to Michael Ignatieff's federal election campaign.

With the 2013 election approaching and Colin Hansen retiring in his Vancouver-Quilchena riding, the 54-year old Wilkinson stood for the BC Liberal nomination.

As the 40th Parliament of British Columbia began, Premier Christy Clark appointed Wilkinson as the Minister of Technology, Innovation and Citizens' Services on June 10, 2013.

[21] Amongst the sales was 5750 Panorama Drive in Surrey to Fairborne Lands LTD that had been previously earmarked as the site for a new hospital by premier Gordon Campbell.

[28] Following a January, 2017 article in The New York Times entitled "British Columbia: The 'Wild West' of Canadian Political Cash"[29] Wilkinson was delegated to speak on behalf of the BC Liberal party, saying: "No one gets special treatment by being a campaign donor," and "It's a system that works."

The BC Liberal Party won the largest number of seats on election night but not enough to form a majority government.

He made the announcement at the Pan Pacific Hotel in Coal Harbour with fellow BC Liberal MLAs Michelle Stilwell, Mary Polak and John Rustad, Doug Clovechok and Tom Shypitka endorsing him.

[37] On November 8 he participated in a province-wide televised debate against Premier John Horgan who argued in favour of proportional representation.

On October 10, 2020, the host of This is Vancolour, Mo Amir, released footage of a BC Liberal roast for retiring MLA Ralph Sultan.