Directed by Marianne Elliott, (associate director at the Royal Court Theatre), the cast featured Will Ash (Lewis), Kate Duchene (Jan), Stephanie Leonidas (Dani) and Andrew Woodall (Tim).
In 2020 a new production was staged at the Orange Tree Theatre in Richmond upon Thames in the UK, directed by Oscar Toeman, with John Hollingsworth as Tim, Jessica Rhodes as Dani, Ali Barouti as Lewis and Alexandra Gilbreath as Jan. Peter Mason, reviewing the production in the Morning Star newspaper, said: "While the play itself is electrifying, the acting from the outstanding cast of four generates its own static charge, creating an atmosphere that occasionally makes the hair stand on end.
"[6] The CurtainUp reviewer wrote: "Ms Prebble weaves her plot with originality and an excellent ear for dialogue.
"[2]The British Theatre Guide reviewer wrote: "Some of the motivations are a little awry and Lucy Prebble tries to put too many complications into her first play.
"[4]The Independent reviewer wrote: "The Sugar Syndrome [is a] remarkably assured, funny and perceptive debut play by twenty-two-year-old Lucy Prebble.