Andrey Vassilyevich Prokofyev (Russian: Андрей Васильевич Прокофьев; 6 June 1959 – 19 June 1989) was a Soviet athlete, winner of a gold medal in the 4 × 100 m relay at the 1980 Summer Olympics.
After retiring and working as a coach, he committed suicide by hanging in 1989.
At the Moscow Olympics, Prokofyev was fourth in the 110 m hurdles and won the gold medal running the anchoring leg of the Soviet 4 × 100 m relay team.
At the 1982 European Championships, Prokofyev won the silver medal in the 110 m hurdles and again a gold in the 4 × 100 m relay.
At the first World Championships, Prokofyev was eliminated in the heats of the 110 m hurdles, but won a bronze medal as a member of the Soviet 4 × 100 m relay team.