Dudith was born in Buda, capital city of the Kingdom of Hungary to a Hungarian noble family with Croatian origins.

Being appointed bishop of Pécs, Dudith went to Poland in 1565 as ambassador of Maximilian, where he married, and resigned his see, becoming an adherent of Protestantism.

After the election of Stephen Báthory as king of Poland, Dudith left Kraków and went to Wrocław and later to Moravia, where he supported the Bohemian Brothers.

Dudith maintained a correspondence with famous Anti-trinitarians such as Giorgio Blandrata, Jacob Paleologus and Fausto Sozzini.

Mihály Balázs, an expert on Central-European Anti-trinitarianism, affirms that Paleologus in Kraków lived in Dudith's house and left there to go to Transylvania.