After the fall of Constantinople in 1453, Kallistos went to Italy where he joined Basilios Bessarion.
He began the systematic teaching of Greek literature in France.
He communicated the principles of Aristotelian thought to many of his students, whose learning won them distinction in Europe.
He traveled extensively in northern Europe and died about 1476 in London, England.
Among his works is a defence of Theodore of Gaza's positions against the criticisms of Michael Apostolius (Andronicus Callistus Defensio Theodori Gazae adversus Michaelem Apostolium).