During his marriage to writer and producer Susan Borowitz (1982–2005), the two co-created The Fresh Prince of Bel-Air,[6] which ran for six seasons on NBC and launched the acting career of Will Smith.

[8] In 1998, Borowitz co-produced the film Pleasantville, starring Reese Witherspoon, Tobey Maguire, William H. Macy, Joan Allen, and Jeff Daniels.

[7] It was nominated for three Academy Awards, including Best Art Direction-Set Decoration, Best Costume Design, and Best Music, Original Dramatic Score.

He has made numerous appearances on other television programs including Countdown with Keith Olbermann, Best Week Ever on VH1 and Live at Gotham on Comedy Central.

Tom Shales, television critic for The Washington Post, singled out Borowitz for praise, calling him "one of the wittiest Web wags".

[11] Borowitz's success as a television performer led to his becoming a strong draw as a stand-up comedian, and he started headlining at major comedy clubs across the country, including Carolines on Broadway, where he hosts a monthly show called Next Week's News.

He also performed to a sold-out house at the 2007 New York Comedy Festival, which featured other prominent comedians including Denis Leary, Bill Maher, and Sarah Silverman.

The show earned rave reviews and featured such guests as Arianna Huffington, Mo Rocca, Jonathan Alter, Joy Behar, and Jeffrey Toobin.

The university newspaper, Daily Nexus, reported that Borowitz played to a packed house and had the audience "erupting with laughter".

[13] Comedian Mike Birbiglia praised Borowitz in a May 2009 profile in Harvard Magazine: "Andy just picked up stand-up comedy as a hobby, and he's as good at it as anybody.

"[14] On November 28, 2010, CBS News Sunday Morning aired a retrospective of his career as a comedian and writer, calling him "one of the funniest people in America".

In a feature about the book, The Washington Post noted its popular success, calling Borowitz "America's finest fake-news creator and sharpest political satirist".

A mixture of dark comedy, hospital drama and love story, the book became a bestseller on its first day of release, placing number one on Amazon's Kindle Single chart.

[18] In his book review for The New York Times, Dwight Garner wrote, "Andy Borowitz is the funniest human on Twitter, and that's not mean praise.

"[19] In his review of the book, journalist Seth Mnookin wrote, "Borowitz has become one of the most lauded satirists in the country—think of him as a literary Jon Stewart.

His name graces the cover of one of the most successful Library of America volumes ever (The 50 Funniest American Writers* (*According to Andy Borowitz)).

What makes An Unexpected Twist even more satisfying is his ability to highlight some of the surreal and infuriating aspects of modern American medical care without hitting the reader over the head with them.