He is also known for recurring roles in two television series: the farmer Cully Wilson in CBS's Lassie and as the neighbor George MacMichael on ABC's The Real McCoys.

At age 19, he toured Scotland with Durward Lely & Company, playing Connor Martin in the romantic Irish musical costume drama The Wearin’ o’ the Green.

[4][5][6] In 1912,[7] Clyde first came to the United States on tour in the Graham Moffat Players, playing the part of Bob Dewar in a vaudeville comedy sketch depicting tenement life in Glasgow called The Concealed Bed.

[8][9][10][11] Years later, at the invitation of his close friend James Finlayson, he returned to the United States in 1920 to join producer Mack Sennett's roster of comedians.

Columbia Pictures launched its short subject department in 1934 and Andy Clyde was one of the first comedy stars signed by producer Jules White.

Unlike many of the Columbia short-subject comedians who indulged in broad facial and physical gestures, Clyde was subtler and more economical: his comic timing was so good that he could merely lift an eyebrow, shudder slightly, or mutter "My, my, my" for humorous effect.

He almost always appeared as a supporting actor: for example, he played a sad provincial constable in the Katharine Hepburn film The Little Minister and Charles Coburn's drinking buddy in The Green Years.

These reductions were not due to any loss in Clyde's popularity; gradual budget cuts forced the studio to make fewer short subjects.

You Were Never Uglier (1944), for example, was remade in 1952 as Hooked and Rooked, with Andy Clyde and Emmett Lynn repeating their roles in the new sequences, but with new female co-stars replacing the vintage-1944 players.

Clyde guested in several other early series as well, including The People's Choice, Soldiers of Fortune, My Little Margie, The Bob Cummings Show, and (as a crafty rural detective) Lock Up.

In 1961, on CBS's The Andy Griffith Show, Clyde played Frank Myers, an eccentric old man whom the town tries to evict in the episode "Mayberry Goes Bankrupt".

In Rory Calhoun's CBS western series The Texan, he played Wild Jack Hastings in "The Troubled Town" and in additional segments as the character Andy Miles.

Clyde further guest-starred in such westerns as Wagon Train, Tales of the Texas Rangers, The Restless Gun, Jefferson Drum, Buckskin, Fury, Shotgun Slade, and The Life and Legend of Wyatt Earp (as Billy Buckett).

As "Scatterbrain Gibbs", he appeared with Tol Avery as Barnes in "Queen of Dixie"; in the story line, series character Christopher Colt (Wayde Preston) is aboard a Mississippi River gambling boat and encounters a ring of counterfeiters.

From 1960 to 1962, Clyde was cast as the farmer Pa McBeam in five episodes of the NBC western series The Tall Man, starring Barry Sullivan and Clu Gulager.

On September 23, 1932, Clyde married Elsie Maud Tarron, a former member of the Sennett Bathing Beauties,[12] in Ontario in San Bernardino County, California.