Anentome spinosa is a species of freshwater snail with an operculum, an aquatic gastropod mollusk in the subfamily Anentominae of the family Nassariidae.

[2][3] This Southeast Asian species is currently known from a less than 50-km2 area along the Mekong River, between Khong Island in Laos and Bandan (Ban Dan Ky) in Cambodia.

[4] Like all snails in the clade Neogastropoda, this species is carnivorous.

It feeds on different types of worms and gastropods, often eating other, larger snails after burying themselves and ambushing their prey.

When a male and female mate, they lock together for 8–12 hours.