Part of the Kelem Welega Zone, Anfillo is bordered on the southwest by the Gambela Region, on the north by Jimma Gidami, on the northeast by Yemalogi Welele, and on the east by Sayo.
[2] Based on figures published by the Central Statistical Agency in 2005, this woreda has an estimated total population of 78,777, of whom 38,907 are men and 39,870 are women; 8,795 or 11.16% of its population are urban dwellers, which is greater than the Zone average of 10.9%.
With an estimated area of 1,586.25 square kilometers, Anfillo has an estimated population density of 49.7 people per square kilometer, which is less than the Zone average of 91.7.
The three largest ethnic groups reported in Anfillo were the Oromo (89.66%), the Amhara (4.6%), and the Mao people (4.46%) otherwise known as the Anfillo; all other ethnic groups made up 1.28% of the population.
The majority of the inhabitants observed Ethiopian Orthodox Christianity, with 58.47% reporting that as their religion, while 31.4% were Protestant, and 9.7% Muslim.