[3] Arvanitaki contributed to the field of neurophysiology with research that explored the giant nerve fibres in genera of gastropods, the sea hare Aplysia and the land snail Helix.
[4] Arvanitaki also discovered that regular electrical oscillations could periodically grow in size until a series of action potentials were fired along isolated nerve fibres of the cuttlefish, genus Sepia.
[4] A further contribution of Arvanitaki was the demonstration that a neuronal circuit was not required for a single nerve to produce rhythmic and spontaneous activity.
Arvanitaki and her husband Chalazonitis both explored the methodology of electrophysiological activity of the nervous system of the sea hare genus Aplysia.
[5] In 1955, Arvanitaki and Chalazonitis[6] as well as Ladislav Tauc[7] created the first intracellular recordings of large neurons of the California sea hare.