The priest Joaquín María Giraldo is considered the first pioneer of the region and the original founder of the town.

After the gold rush, settlers arrived in the region until, in 1887, a pair of them, the brothers Joaquín and Petrona Franco, decided to build a chapel on a mountainous ridge they called "Los Ángeles."

They were accompanied by the aforementioned Father Joaquín María Giraldo, who would become an icon of the population and who proposed the name "Angelópolis" for the recent foundation.

This area, of immense value in ecotourism, attracts more and more ecotourists and hikers, and is the cradle of several rivers, and is home to many species of flora and fauna.

It is connected by road to the municipalities of Heliconia, La Estrella, Caldas, Amagá, Titiribí, Armenia, and Medellín.