[5][6] Between December 1992 and September 1998, Griffin appeared in the popular long-running ITV soap opera Coronation Street as hairdresser Fiona Middleton.

[8][9] In October 2001 Griffin presented Brown Britain, a programme on the UK's Channel 4 about mixed race people in British society.

The show included interviews with a large number of well-known British mixed-race people such as Bruce Oldfield and Hanif Kureishi, as well as political figures such as Tony Benn.

[11] From November 2009 to July 2010, Griffin hosted her own live daytime show on Sky1 called Angela and Friends, a mix of health topics and celebrity gossip.

In January 2022, it was announced that Griffin would once again reprise her role as Kim Campbell for a new series of Waterloo Road, with her character now promoted to Head Teacher.

[19] In April 2022, Griffin starred in the Netflix horror film Choose or Die, playing the main protagonist's mother, Thea.

In May 2022, Griffin voiced the eponymous Medea in OpenLearn's animated video summary of Euripides' ancient Greek tragedy play.