[citation needed] After training as a shorthand typist Domröse worked in a state-run foreign trade enterprise in East Germany.
In 1966 she joined the Berliner Ensemble, where among other things she performed in Brecht's Dreigroschenoper, Schwejk im zweiten Weltkrieg and Die Tage der Commune, as well as in Helmut Baierl's Frau Flinz.
She later worked with the Volksbühne Berlin until 1979, with whom she performed in plays by George Bernard Shaw, William Shakespeare and Peter Hacks.
In 1971, 1973 and 1975 she was nominated television actress of the year, and in 1976 she won the National Prize of East Germany.
In 1958, Domröse was discovered by director Slatan Dudow during a casting for the film Verwirrung der Liebe (Love's Confusion).